Dr. Henry Jekyll believes that there are two distinct sides to men - a good and an evil side. He believes that by separating the two, man can become liberated. He succeeds in his experiments with chemicals to accomplish this and transforms into Hyde to commit horrendous crimes. When he discontinues use of the drug, it is already too late.
| Writing | Samuel Hoffenstein | Screenplay |
| Camera | Karl Struss | Director of Photography |
| Art | Hans Dreier | Art Direction |
| Directing | Rouben Mamoulian | Director |
| Production | Adolph Zukor | Executive Producer |
| Editing | William Shea | Editor |
| Production | Rouben Mamoulian | Producer |
| Writing | Percy Heath | Screenplay |
| Costume & Make-Up | Travis Banton | Costume Design |
| Writing | Robert Louis Stevenson | Novel |
| Costume & Make-Up | Wally Westmore | Special Effects Makeup Artist |
| Crew | Chick Collins | Stunts |
| Sound | John Leipold | Music |
| Camera | Fleet Southcott | Assistant Camera |
| Camera | Harry Hallenberger | Additional Camera |
| Sound | Rudolph G. Kopp | Music |
| Sound | Ralph Rainger | Music |
| Camera | Gordon Head | Still Photographer |
| Costume & Make-Up | Norbert A. Myles | Makeup Artist |
| Sound | Herman Hand | Music |
| Sound | M.M. Paggi | Sound |
| Camera | George T. Clemens | Additional Camera |
| Camera | Charles Leahy | Assistant Camera |
| Directing | Robert Lee | Assistant Director |
| Camera | Cliff Shirpser | Assistant Camera |
