Will Lockhart arrives in Coronado, an isolated town in New Mexico, in search of someone who sells rifles to the Apache tribe, finding himself unwillingly drawn into the convoluted life of a local ranching family whose members seem to have a lot to hide.
Headstrong Thomas Dunson starts a thriving Texas cattle ranch with the help of his faithful trail hand, Groot, and his protégé, Matthew Garth, an orphan Dunson took under his wing when Matt was a boy. In need of money following the Civil War, Dunson and Matt lead a cattle drive to Missouri, where they will get a better price than locally, but the crotchety older man and his willful young partner begin to butt heads on the exhausting journey.
El Mariachi just wants to play his guitar and carry on the family tradition. Unfortunately, the town he tries to find work in has another visitor, a killer who carries his guns in a guitar case. The drug lord and his henchmen mistake el Mariachi for the killer, Azul, and chase him around town trying to kill him and get his guitar case.
Chico one of the remaining members of The Magnificent Seven now lives in the town that they (The Seven) helped. One day someone comes and takes most of the men prisoner. His wife seeks out Chris, the leader of The Seven for help. Chris also meets Vin another member of The Seven. They find four other men and they go to help Chico.
Legless Southern inventor Dr. Arliss Loveless plans to rekindle the Civil War by assassinating President U.S. Grant. Only two men can stop him: gunfighter James West and master-of-disguise and inventor Artemus Gordon. The two must team up to thwart Loveless' plans.
Chon Wang, a clumsy imperial guard trails Princess Pei Pei when she is kidnapped from the Forbidden City and transported to America. Wang follows her captors to Nevada, where he teams up with an unlikely partner, outcast outlaw Roy O'Bannon, and tries to spring the princess from her imprisonment.
A band of Mexicans find their U. S. land claims denied and all the records destroyed in a courthouse fire. Their leader, Louis Chama, encourages them to use force to regain their land. A wealthy landowner wanting the same decides to hire a gang of killers with Joe Kidd to track Chama.
Fred C. Dobbs and Bob Curtin, both down on their luck in Tampico, Mexico in 1925, meet up with a grizzled prospector named Howard and decide to join with him in search of gold in the wilds of central Mexico. Through enormous difficulties, they eventually succeed in finding gold, but bandits, the elements, and most especially greed threaten to turn their success into disaster.
In 1870s America, a peaceful American settler kills his family's murderer which unleashes the fury of a notorious gang leader. His cowardly fellow townspeople then betray him, forcing him to hunt down the outlaws alone.
In the lawless West, The Cowboys, a notorious brotherhood of killers and thieves, reigned over the land with brutal fists and fast guns. Fate had finally caught up with them and now the merciless gang has but a single surviving member. When a deputized gunslinger takes up the call to hunt down the last Cowboy, the chase is on and the bullets fly, and only one of these hardened men can survive.
Texas Ranger Jake Cutter arrests gambler Paul Regret, but soon finds himself teamed with his prisoner in an undercover effort to defeat a band of renegade arms merchants and thieves known as Comancheros.
A band of murderous cowboys has imposed a reign of terror on the town of Warlock. With the sheriff humiliatingly run out of town, the residents hire the services of Clay Blaisedell as de facto town marshal. He arrives along with his friend, Tom Morgan, and sets about restoring law and order on his own terms whilst also overseeing the establishment of a gambling house and saloon.
A group of young gunmen, led by Billy the Kid, become deputies to avenge the murder of the rancher who became their benefactor. But when Billy takes their authority too far, they become the hunted.
Some time after the Mousekewitz's have settled in America, they find that they are still having problems with the threat of cats. That makes them eager to try another home out in the west, where they are promised that mice and cats live in peace. Unfortunately, the one making this claim is an oily con artist named Cat R. Waul who is intent on his own sinister plan.