For Tammy, a burger-joint employee, a bad day keeps getting worse. She wrecks her car, loses her job and finds that her husband has been unfaithful. It's time for Tammy to hit the road, but without money or transportation, her options are limited. Her only choice is a road trip with her hard-drinking grandmother, Pearl, who has a car, cash and an itch to see Niagara Falls. It's not the escape Tammy had in mind, but it may be what she needs.
| Directing | Ben Falcone | Director |
| Writing | Ben Falcone | Writer |
| Writing | Melissa McCarthy | Writer |
| Sound | Michael Andrews | Original Music Composer |
| Sound | Manish Raval | Music Supervisor |
| Sound | Tom Wolfe | Music Supervisor |
| Sound | Manish Raval | Music Editor |
| Camera | Michael Tackett | Still Photographer |
| Costume & Make-Up | Kate Shorter | Makeup Department Head |
| Costume & Make-Up | Linda D. Flowers | Hair Department Head |
| Art | Jefferson Sage | Production Design |
| Camera | Russ T. Alsobrook | Director of Photography |
| Costume & Make-Up | Wendy Chuck | Costume Design |
| Editing | Michael L. Sale | Editor |
| Sound | Ronald J. Webb | Music Editor |
| Production | Allison Jones | Casting |
| Art | Richard Fojo | Art Direction |
| Art | Marthe Pineau | Set Decoration |
| Editing | Mikki Levi | First Assistant Editor |
| Sound | Andrew DeCristofaro | Supervising Sound Editor |
| Sound | Becky Sullivan | Supervising Sound Editor |
| Sound | Gregg Landaker | Sound Re-Recording Mixer |
| Sound | Steve Maslow | Sound Re-Recording Mixer |
| Directing | Sheila Waldron | Script Supervisor |
| Production | Adam McKay | Producer |
| Production | Melissa McCarthy | Producer |
| Production | Will Ferrell | Producer |
| Production | Rob Cowan | Executive Producer |
| Production | Ben Falcone | Executive Producer |
| Production | Richard Brener | Executive Producer |
| Production | Kevin J. Messick | Executive Producer |
| Production | Chris Henchy | Executive Producer |
| Production | Michael Disco | Executive Producer |
| Production | Toby Emmerich | Executive Producer |
| Costume & Make-Up | Nava R. Sadan | Costume Supervisor |
| Costume & Make-Up | Margaret Robbs | Assistant Costume Designer |
| Costume & Make-Up | Ma Kalaadevi Ananda | Makeup Artist |
| Costume & Make-Up | Daniel Curet | Key Hair Stylist |
| Costume & Make-Up | Jennifer Zide | Makeup Artist |
| Costume & Make-Up | Jorie Malan | Makeup Artist |
| Costume & Make-Up | Elisabeth Fry | Makeup Artist |
| Costume & Make-Up | Colleen LaBaff | Hairstylist |
| Art | Amy Tipton | Art Department Coordinator |
| Crew | David Beavis | Special Effects Coordinator |
| Sound | Laura Harris Atkinson | Dialogue Editor |
| Sound | Michael Rayle | Sound Mixer |
| Art | Tim Schultz | Property Master |
| Sound | Michael Payne | Sound Effects Editor |
| Crew | Jimmie Lee Sessoms | Stunts |
| Crew | Rosie Bernhard | Stunts |
