After solving their last mystery at Spooky Island, the Mystery Inc. gang is back in Coolsville, where they are being honored with their very own exhibit at the Coolsonian Criminology Museum. However, when a masked villain steals costumes of classic monsters on display and brings them to life, the gang must come out of retirement to solve the case.
| Directing | Raja Gosnell | Director |
| Camera | Oliver Wood | Director of Photography |
| Production | Joseph Barbera | Executive Producer |
| Production | Brent O'Connor | Executive Producer |
| Production | Kelley Smith-Wait | Executive Producer |
| Production | Charles Roven | Producer |
| Production | Richard Suckle | Producer |
| Editing | Kent Beyda | Editor |
| Sound | David Newman | Original Music Composer |
| Visual Effects | Brian Dowrick | Animation |
| Visual Effects | Matt Williames | Animation |
| Directing | Steeve Boulianne | Layout |
| Visual Effects | Andrew Arnett | Animation |
| Visual Effects | Leigh H. Rens | Animation |
| Visual Effects | Jeff Croke | Animation |
| Visual Effects | Chris Lentz | Animation |
| Visual Effects | Steve Harwood | Animation |
| Visual Effects | Hugo Dominguez | Visual Effects |
| Visual Effects | Steve Cady | Animation |
| Crew | Bill Haller | Supervising Animator |
| Visual Effects | Angie Jones | Animation |
| Visual Effects | Kristin Solid | Animation |
| Production | Alan Glazer | Co-Producer |
| Production | Mary Vernieu | Casting |
| Production | Richard Cowan | Associate Producer |
| Production | James Gunn | Co-Producer |
| Crew | James Bamford | Stunts |
| Crew | J.J. Makaro | Stunt Coordinator |
| Art | Don MacAulay | Art Direction |
| Art | John Alvarez | Assistant Art Director |
| Camera | Steven J. Winslow | Camera Technician |
| Art | Shepherd Frankel | Supervising Art Director |
| Art | Bill Boes | Production Design |
| Art | Michael N. Wong | Art Direction |
| Art | Constantine Sekeris | Conceptual Design |
| Costume & Make-Up | Leesa Evans | Costume Design |
| Art | Mira Caveno | Set Designer |
| Camera | Rick Allen | Grip |
| Art | Peter Ochotta | Art Department Assistant |
| Art | Brad Oleksy | Greensman |
| Writing | Joseph Barbera | Characters |
| Writing | William Hanna | Characters |
| Art | Daphne Klebe | Art Department Coordinator |
| Art | Brent Gloeckler | Sculptor |
| Art | Tedd Kuchera | Set Decoration |
| Art | Warren Dunlop | Construction Foreman |
| Camera | Glen A. Dickson | Additional Camera |
| Art | Brian Shell | Construction Coordinator |
| Camera | Sandes Ashe | First Assistant Camera |
| Crew | Dwane McIsaac | Chef |
| Crew | Ray Evans | Driver |
| Crew | Lance Johnson | Property Master |
| Sound | Jeff Glueck | Sound Engineer |
| Visual Effects | Laide Agunbiade | Digital Compositors |
| Crew | Laura Boddington | Stand In |
| Crew | Nick Allen | Stunts |
| Crew | László Sebõ | Technical Supervisor |
| Visual Effects | Mathieu Blouin | Animation Supervisor |
| Visual Effects | David Zbriger | I/O Supervisor |
| Visual Effects | Mike Splatt | Special Effects Supervisor |
| Production | Mandy Butler | Production Accountant |
| Sound | Gregory Jamrok | Orchestrator |
| Crew | Ivan Neulander | Software Engineer |
| Production | Daniel R. Chavez | Executive In Charge Of Post Production |
| Sound | Michael D. Wilhoit | Supervising Sound Editor |
| Crew | Erika A. McKee | Digital Producer |
| Costume & Make-Up | Bill Terezakis | Prosthetic Supervisor |
| Crew | Tony Swatton | Armorer |
| Crew | Patrick Booker | Carpenter |
| Crew | Fernando Favila | Makeup Effects |
| Editing | Valance Eisleben | Editorial Services |
| Crew | Joan Kelley Bierman | Post Production Supervisor |
| Editing | Matt Diezel | Assistant Editor |
| Lighting | Christopher Charles Kempinski | Lighting Technician |
| Sound | Kelly Zombor | Boom Operator |
| Costume & Make-Up | Anji Bemben | Hairstylist |
| Costume & Make-Up | Gitte Axen | Makeup Artist |
| Costume & Make-Up | Luisa Dalmagro | Set Costumer |
| Crew | Steve Ellis | Transportation Captain |
| Crew | Ronald Schlueter | Video Assist Operator |
| Sound | Scott Wolf | Sound Designer |
| Sound | Karen Schell | Sound |
| Camera | Dan Mannix | Steadicam Operator |
| Crew | Peter Huff | Transportation Coordinator |
| Crew | Daniel Arkin | Visual Effects Editor |
| Sound | David Husby | Production Sound Mixer |
| Sound | Kerry Ann Carmean | Sound Effects Editor |
| Visual Effects | Melany Bourgouin | Visual Effects Coordinator |
| Visual Effects | Stephanie Allen | Visual Effects Producer |
| Lighting | John Lai | Lighting Artist |
| Lighting | Cory Hodson | Rigging Gaffer |
| Production | Juliet Verni | Production Coordinator |
| Sound | Chris Hogan | Sound Editor |
| Lighting | Ronnie Baran | Best Boy Electric |
| Production | Rif Dagher | Researcher |
| Visual Effects | Conrad Dueck | 3D Supervisor |
| Crew | Joey Lessard | CG Supervisor |
| Crew | Michael Shand | CGI Supervisor |
| Lighting | Tim Atkins | Gaffer |
| Production | Kirk Johns | Location Manager |
| Production | Julia Frittaion | Publicist |
| Sound | Darren Higman | Music Supervisor |
| Visual Effects | Benton Jew | Creature Design |
| Camera | Tim Arasheben | Helicopter Camera |
| Crew | Jim Rankin | Craft Service |
| Production | Charles Lyall | Production Manager |
| Visual Effects | Chris Bond | Visual Effects Supervisor |
| Visual Effects | Keith Hunter | Modeling |
| Camera | Diyah Pera | Still Photographer |
| Crew | Todd Shifflett | Digital Effects Supervisor |
| Visual Effects | August Hall | Visual Development |
| Crew | David Allinson | Special Effects Coordinator |
| Crew | Steve Linn | Systems Administrators & Support |
| Production | Brent O'Connor | Unit Production Manager |
| Crew | Cody Laudan | Utility Stunts |
| Sound | Markus Czyzewski | Music Editor |
| Crew | Rick Rasmussen | Picture Car Coordinator |
| Production | Bill Draper | Executive In Charge Of Production |
| Sound | Mark Kenna | Dolby Consultant |
| Crew | Chris Bradford | Security |
| Crew | Andy Armstrong | Stunt Coordinator |
| Lighting | Raymond Chen | Lighting Supervisor |
| Art | Perry Battista | Lead Set Dresser |
| Costume & Make-Up | Stacey Butterworth | Wig Designer |
| Directing | David Klohn | Second Assistant Director |
| Visual Effects | Kelvin Lee | Lead Animator |
| Crew | Barrie Wells | Techno Crane Operator |
| Visual Effects | Mitch Gates | Visual Effects Technical Director |
| Costume & Make-Up | Alison Fraser | Costume Coordinator |
| Directing | Misha Bukowski | Third Assistant Director |
| Production | Jody Chow | Assistant Production Coordinator |
| Art | Tracy B. Dunlop | Set Dresser |
| Camera | Todd Hlagi | Dolly Grip |
| Crew | Jim Filippone | Pilot |
| Lighting | Dennis Brock | Chief Lighting Technician |
| Sound | Jeff Carson | Supervising Music Editor |
| Sound | Tom Boyd | Musician |
| Sound | Kelly Oxford | ADR Editor |
| Sound | David Kudell | Assistant Sound Editor |
| Sound | Laura Harris Atkinson | Supervising Dialogue Editor |
| Directing | Richard Cowan | First Assistant Director |
| Camera | Tim Hogan | Key Grip |
| Camera | Jim Filippone | Helicopter Camera |
| Crew | Jason Crosby | Marine Coordinator |
| Production | James McKenzie Moore | Casting Assistant |
| Art | Santino Barile | Assistant Property Master |
| Sound | Diana Stata | Assistant Music Supervisor |
| Visual Effects | Adam de Bosch Kemper | Pre-Visualization Supervisor |
| Editing | Mo Henry | Negative Cutter |
| Crew | Anne Fletcher | Choreographer |
| Camera | Jim Bacon | Epk Producer |
| Production | Jina Johnson | Assistant Location Manager |
| Production | Eve-Marie Gingras | Production Supervisor |
| Sound | David Newman | Conductor |
| Lighting | Jeff Hall | Assistant Chief Lighting Technician |
| Lighting | Herb DeWaal | Key Rigging Grip |
| Visual Effects | Marta Knudsen | Matte Painter |
| Sound | Eric Gotthelf | ADR Mixer |
| Visual Effects | Lindsay Hallett | Visual Effects Production Manager |
| Editing | Lionel Barton | Colorist |
| Visual Effects | Will Cunningham | Compositing Artist |
| Production | Jamie Reid Tait | Second Assistant Production Coordinator |
| Visual Effects | Cheryl Budgett | 2D Supervisor |
| Crew | Jim Bach | Playback Coordinator |
| Editing | James Bluma | Assistant Editor |
| Editing | Anthony Harris | Digital Color Timer |
| Sound | Nerses Gezalyan | Foley Mixer |
| Camera | Michael Lemmers | Best Boy Grip |
| Directing | Joanna Moore | Second Second Assistant Director |
| Art | Sean Lavoie | Paint Coordinator |
| Crew | Jim Dunn | Stunt Double |
| Camera | Jim Van Dijk | First Assistant "A" Camera |
| Costume & Make-Up | Elizabeth Beauchamp | Costumer |
| Art | Leah Hong | Graphic Designer |
| Crew | Jay Anderson | Generator Operator |
| Art | Shaun Bullied | Set Painter |
| Art | Brom | Storyboard Artist |
| Crew | Jason Piccioni | Digital Supervisor |
| Costume & Make-Up | Cydney Cornell | Hairdresser |
| Visual Effects | Jacques Levesque | Compositing Supervisor |
| Directing | Andy Armstrong | Second Assistant Director |
| Production | Errin Lally | Casting Coordinator |
| Editing | Ron Barr | Digital Intermediate Editor |
| Production | Suzie Bruce | Assistant Accountant |
| Crew | Darya Douglas-Andres | Special Effects Assistant |
| Crew | Mike Larivee | Special Effects Technician |
| Camera | Harold Bernard | Second Assistant Camera |
| Production | Barbara Copp | Key Production Assistant |
| Costume & Make-Up | Tamar Ouziel | Assistant Makeup Artist |
| Costume & Make-Up | Rob Miller | Contact Lens Technician |
| Sound | James Moriana | Foley Artist |
| Production | Stephanie Boeke | Extras Casting |
| Visual Effects | Whitney Kitchen | Animation Coordinator |
| Sound | Kimaree Long | Dialogue Editor |
| Sound | Michael Buffer | Musician |
| Writing | James Gunn | Writer |
| Crew | Doug Chapman | Stunts |
| Crew | Adam Shankman | Choreographer |
| Crew | Melissa R. Stubbs | Stunts |
| Directing | John MacCarthy | Second Unit First Assistant Director |
| Crew | Crystal Dalman | Stunts |
| Crew | Alette Falle | Stunts |
| Crew | Richard Brooks | Stunts |
| Crew | Ashlea Earl | Stunts |
| Crew | Nesta Chapman | Stunts |
| Crew | Jeff Sanca | Stunts |
| Crew | Laurence Todd Rosenthal | Stunts |
| Crew | Dustin Brooks | Stunts |
| Crew | Leanne Buchanan | Stunts |
| Crew | Paul Becker | Stunts |
| Crew | Jim Bentley | Stunts |
| Crew | Melissa Barker | Stunts |
| Crew | James Bamford | Martial Arts Choreographer |
| Crew | Claude Bouchard | Stunts |
| Crew | Bill Edwards | Stunts |
| Crew | Tom Farr | Stunts |
| Crew | Brent Connolly | Stunts |
| Crew | Beverly Knight | Stunts |
| Crew | Dave Hospes | Stunts |
| Crew | Mitchell A. Lee Yuen | Stunts |
| Crew | Nicholas Harrison | Stunts |
| Crew | Brad Loree | Stunts |
| Crew | Deb Macatumpag | Stunts |
| Crew | Brian Lydiatt | Stunts |
| Crew | Gaston Morrison | Stunts |
| Crew | Cotton Mather | Stunts |
| Crew | Scott Nicholson | Stunts |
| Crew | Todd W. Nobles | Stunts |
| Crew | Heath Stevenson | Stunts |
| Crew | Michele Waitman | Stunts |
| Crew | Angela Uyeda | Stunts |
| Crew | David Mylrea | Stunts |
